The Women’s Clinic of the AMC organises in collaboration with SYRCLE (SYstematic Review Centre for Laboratory animal Experimentation) a one-day workshop entitled: synthesis of evidence in animal experimentation.
From information to knowledge through systematic reviews.
Date: Friday June 3rd 2016

‘Synthesis of evidence’ refers to structured and transparent methods to thoroughly analyse studies already conducted and published in a particular field. In clinical research, one type of synthesis of evidence, namely systematic review, is already common practice. In the field of animal experimentation, however, systematic reviews are still rather uncommon, even though recent publications have shown that they have several important advantages. For example, systematic reviews may help improve the scientific quality of animal experiments, they may prevent unnecessary (duplication of) experiments and they may improve the translation of animal data to the clinic, thereby increasing patient safety. In addition, meta-analyses may provide quantitative summaries of the results of the animal studies on a certain topic.
In this workshop, you will be introduced to the concepts of synthesis of evidence and systematic reviews of animal studies and to the differences between these review methods and classical, so-called narrative reviews. Both the advantages and the limitations of systematic reviews will be discussed. Moreover, you will get the opportunity to actually practice the steps of which systematic reviews typically consist. Through this practical experience you will get a good idea about the added value of systematic reviews and about the possibilities and efforts needed for conducting such a review in your own field of research. Since 2009, SYRCLE has been developing education, tools and guidelines to promote and facilitate the performance of systematic reviews of animal studies.


We cordially invite you to participate in this hands-on training in systematic reviews of animal experiments.
For whom?
This hands-on training is for (biomedical) researchers directly or indirectly involved in animal experiments. The course is open to and suitable for PhD students, postdoctoral researchers as well as more senior researchers.
• Registration for this workshop can be made by sending an e-mail to (name, affiliation, ‘Workshop’).
• The workshop is free for scientist affiliated with Dutch knowledge institutes, thanks to funding by ZonMw.
• ZonMw criterion for payment is actual presence at June 3rd: in case of no-show (without legitimate reason), we will be obliged to charge the actual workshop fee of €350.
• Registration is on first-come, first served basis and will be limited to 23 participants.
• Cancellation of registration can be made up to May 20th.


In case of questions please sent an e-mail to
Preliminary program
• Host: Cornelieke van de Beek, Women’s Clinic AMC
• Time/location: 9:00 – 17:00, AMC

Lecture: Introduction to systematic reviews of animal studies
Part 1. Identifying and selecting relevant studies
• Introductory lecture: Identify ‘all’ relevant animal studies
• Computer practical 1a: Develop comprehensive search strategies
• Computer practical 1b: Inclusion / exclusion of studies
Part 2. Assessing study validity
• Introductory lecture: Validity of animal studies Workshop assignment 2a: Criteria of validity
• Workshop assignment 2b: Risk of bias assessment
Part 3. Data extraction and synthesis
• Introductory lecture: Data extraction and meta-analysis
• Computer practical 3a: data extraction
• Computer practical 3b: data synthesis / meta-analysis